Department of Chemistry

Ever since 2000 Dr. Sci., Professor Tatyana A. Gudasheva is the Head of Chemistry Department. tel.: (495) 601-2373, 601-2246

Scope of Basic Department Research activities:

• design, synthesis, SAR  investigation and translation into medical practice of medicaments with psychotropic and cardiovascular profiles. This work is based on compounds which are structural or functional analogs of the known endogenous transmitters or neuromodulators, such as regulatory peptides, classical neurotransmitters and others;

   

• search of methods applicable for the synthesis of chemical compounds belonging to classes of interest for the search for novel basic structures;

   

• design of optimal charts for the synthesis of selected potential drugs and their production for the further comprehensive pharmacological investigation.

   

The chemical studies and search for potential medicines is performed among chemical substances of the following groups:

• substituted dipeptides and cyclopeptides;

   

• derivatives naturally occurring and synthetic aminoacids;

   

• derivatives of pyrrol and its condensed systems;

   

• nicotinic acid derivatives;

   

• derivatives of pyrido[1,2-a]pyrimidines and relative systems;

   

• derivatives of 2-mercaptobenzimidazole

   

• Derivatives of 3-benzoylpyridines;

   

• 4-aminopyridinecarbonic acids derivatives;

   

• 4-phenylpyrrolidine derivatives;

   

• derivatives of tetrahydropyrido[4,5-c]pyrazoles;

   

• N-acyl derivatives of dibenzoazepines and dibenzodiazepines;

   

• tropane derivatives;

   

• 3,4 – substituted cumarines

   

The researchers of the Department have supported 4 Doctor Sci. and 46 Ph.D. theses.

Recent publications:

1. R. U. Ostrovskaya, M.A. Gruden, N.A. Bobkova, R. D. E. Sewell , T. A. Gudasheva, A. N. Samokhin, S. B. Seredеnin, W.Noppe, V.V. Sherstnev, L. A. Morozova-Roche . The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model.// J Psychopharmacol 2007 vol . 21, N 6,  611-619.

    

2. Design and synthesis of cholecystokinin-4 dipeptide analogues with anxiolytic and anxiogenic activities. TA Gudasheva, EP Kir'ianova, LG Kolik, MA Konstantinopol'skii, and SB Seredenin. Bioorg Khim, Jul 2007; 33(4): 413-20. [in Russ.]