Laboratory of Clinical Psychopharmacology

Professor Grigory G. Neznamov (birthdate 1945) heads the Lab. tel.: (495) 601-2362

The Lab is located and operates on premises of 12^th Moscow Psychiatric Hospital.

Main goals of Lab activity are as follows:

• Evaluation of clinical pharmacological patterns of action exerted by novel and widely clinically used psychotropic drugs;
• Scientific research and applied works in diagnosis and correction of psychic adaptation disturbances developed in patients of different groups exposed to unfavorable endogenous factors;
• Introduction into health care affiliations activities of up-to-date accomplishments in experimental and clinical psychopharmacology as consulting, diagnostic, medicinal and therapeutic services.

• Organization and performance of clinical trials with novel psychotropic medicaments;
• Performance of complex experimental clinical trials jointly with other affiliations and Institute subunits aimed to advance the main directions of its scientific activities;
• Education & training (thesis support and practical doctors training in the framework of RAMS clinical internship in "Clinical Pharmacology and Pharmacotherapy").

To achieve the above purposes the Lab performs the research in the following fields:

• Elaboration of methodological basis to assess the individual psychotropic effects and spectral parameters of psychopharmacological agents in clinic. This evaluation has to be comparable with experimental pharmacological findings;
• Complex clinical pharmacological analysis (using clinical, psychological, psychophysiological, pharmaco-EEG and pharmacokinetic methods) of specific activity of anxiolytics, drugs with stimulating action, nootropics and others;
• Study on individual responses to psychotropic drugs determined by human phenotype features
• Assessment of possibility of use and efficacy of anxiolytics, nootrops and stimulants for the correction of general state and operatory performance of patients with psychic adaptation disturbances of different genesis.

Recent publications:

1. SA Siuniakov, SA Grishin, ES Teleshova, GG Neznamov, and SB Seredenin - Pilot clinical trial of ladasten. Eksp Klin Farmakol, Jul 2006; 69(4): 10-5. [in Russ].
2. GM Molоdavkin, TA Voronina, GG Neznamov, OK Meletova, and NV Eliava - Participation of GABA--benzodiazepine receptor complex in the anxiolytic effect of piracetam. Eksp Klin Farmakol, May 2006; 69(3): 7-9. [in Russ].