The Lab was founded in 1976 with the aim to conduct fundamental studies on neurochemical basis underlying the mechanism of action produced by neuropsychotropic substances.
The Lab is headed by Vladimir S. Kudrin (born 1948).
tel.: (495) 601-2153
Main directions of Lab studies:
evaluation of the role the neurotransmitter brain systems play in the mechanism of action produced by neuroleptics and psychostimulants;
investigation of the neuroprotective activity of nootropic peptides and their analogues;
evaluation of the role played by nitrogen oxide, peroxide oxidation of neurotransmitter aminoacids lipids and their receptors in modeling different brain pathologies (convulsive states of different types, mnestic disoders, ischemia, neurotoxic action of amphetamines);
search for substances with neurotropic activity within the family of triasine derivatives (jointly with Ural' State Polytechnic University).
The Lab closely collaborates with the other laboratories of the Institute along with other affiliations: Experimental neurology Department of the Institute of Psychiatry London University (head - M. Meldrum), Brain Institute of Tampere University, Finland (head - S. Oja), Institute of Pharmacology Marburg University, Germany (head - K. Kuschinsky), Institute of Pharmacology Innsbruk, Austria (head - A. Philippu), Institute of Medical Investigations University of T. Jefferson University, Philadelphia, USA (head - D.M. Armstrong).
6 Doctor Sci. and 28 Ph.D. Thesis were supported based on results obtained from the Lab investigations.
Recent publications:
Us K.S., Klodt P.M., Kudrin V.S., SapronovaA.Ya., Ostrovskaya R.U., Ugryumov M.V., RayevskyK.S. The effect of the synthetic neuroprotective dipeptide Noopept onglutamate release from rat brain cortex slices. Neurochem.J., 2007, V.1, No.2,P.138–142.
Vataeva L.A., Kudrin V.S., Vershinina E.A., Mosin V.M., Tiulkova E.I., Otellin V.A. Behavioral alteration in the adult rats prenatally exposed to para-chlorophenylalanine. Brain Res., 2007, V.1169, P.9-16.
Bashkatova V., Vanin A. and Panchenko L. Memory impairement and oxidative stress in the hippocampus of juvenile rats after a prenatal stress induced by amphetamine administration.J. Neurochem., 2007, V. 101, Suppl. 1., P.67.
Bashkatova V., Hornick A., Vanin A., PrastH. Role of M1 receptors in amphetamine-induced neurotoxicity, Abstr.of ISN Satellite Meeting “Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity", 2007, Merida, Mexico, P. 119.
Bashkatova V.,C Chernykh T., Vanin A.. Metabotropic glutamate receptors and nitric oxide in the mechanisms of audiogenic seizures in DBA/2 mice. Behavioral Pharmacology, 2007, V.18. Suppl. 1, P.127.
KS Raevskii, LA Malikova, and VV Kalinin. Neuronal and neurochemical mechanisms underlying the effect of a novel antiepileptic drug levetiracetam. Eksp Klin Farmakol, Mar 2007; 70(2): 70-4.
