The Laboratory was founded in 1984 on the basis of neuropsychotropic drugs screening team.
Ever since 1984 professor Tatyana A. Voronina heads the Laboratory.
tel.: (495) 601-2414.
16 doctoral and 27 Ph.D. theses were prepared and supported in the Lab. These scientists are working successfully in Russia and other countries abroad.
Main lines of scientific research:
Examination of basic mechanisms of action of newly developed and known psychotropic agents with nootropic, anxiolytic, anticonvulsant, antipsychotic and analgetic effects and drugs for treatment and prevention of neurodegenerative diseases (Alzheimer's and Parkinson's diseases, brain ischemia, epilepsy);
Design of novel concepts and targeted search for novel psychotropic substances with selective action among new rows of chemical substances.
Recent publications:
Fedorova K.S., Klodt P.M., Kudrin V.S., Sapronova Ya A., Ostrovskaya R.U., Ugryumov M.V., Rayevsky K.S. The effect of the synthetic neuroprotective dipeptide noopept on glutamate release from rat cortical brain slices. “Neurochem. J.”, 2007, Vol. 1, No. 2, pp. 138-142.
Fedorova T.N., Us K.S., Ostrovskaya R.U. Estimation of the antioxidant effect of the nootropic dipeptide noopept on the model of Fe2+-induced chemiluminescence of lipoproteins of human serum in vitro. “Neurochem. J.”, 2007, Vol. 1, No. 3, pp. 260–263.
Ostrovskaya R.U., Gruden M.A., Bobkova N.A., Sewell R.D.E., Gudasheva T.A., Samokhin A.N., Seredinin S.B., Noppe W., Sherstnev V.V., Morozova-Roche L.A.. The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model. “J Psychopharmacol.” 2007, Vol. 21, No. 6, pp. 611-619.
Us K.S., Klodt P.M., Kudrin V.S., Sapronova A.Ya., Ostrovskaya R.U., Ugryumov M.V., Rayevsky K.S. The effect of the synthetic neuroprotective dipeptide noopept on glutamate release from rat brain cortex slices. “Neurochem. J.”, 2007, Vol. 1, No. 2, pp. 138-142.
Voronina T.A., Sergeeva S.A., Martyushev-Poklad A.V., Dugina J.L., Epstein O.I. Chapter 8. Antibodies to S-100 protein in anxiety-depressive disorders in experimental and clinical conditions. In “Animal models in biological psychiatry”, Ed. Kalueff A.V. N-Y, “Nova Science Publishers, Inc.”, 2006, pp. 137-152.
Ostrovskaya R.U., Seredenin S.B., Voronina T.A., Molodavkin G.M., Gudasheva T.A. On the problem on memory-anxiety interaction: anxiolytic effects on memory-improving dipeptide GVS-111. In “Animal models in biological psychiatry”, Ed. Kalueff A.V. N-Y, “Nova Science Publishers, Inc.”, 2006, pp. 165-182.
PS Gromovykh, LS Guzevatykh, KV Shevchenko, LA Andreeva, LIu Alfeeva, VP Shevchenko, IIu Nagaev, TA Voronina, and NF Miasoedov. Synthesis, pharmacokinetics, and metabolism of the C-terminal tripeptide of dermorphin and its diastereomer. Bioorg Khim, Nov 2007; 33(6): 581-7.[in Russian].
LS Guzevatykh,TA Voronina, TG Emel'ianova, LA Andreeva, PS Gromovykh, NF Miasoedov, and SB Seredenin. Comparative analysis of analgesic activities of dermorphin, [DPro6]-dermorphin, and their C-terminal tripeptides. Izv Akad Nauk Ser Biol, Sep 2007; (5): 577-82. [in Russian].
IuB Deshevoi, BB Moroz, GV Cukoian, TA Voronina, VG Lebedev, and AV Lyrshchikova. Acute radiation sickness in experiment. Efficacy of mexidol. Patol Fiziol Eksp Ter, Jul 2007; (3): 22-4. [in Russian].
TL Garibova, TA Voronina, SA Litvinova, VV Grigor'ev, and SO Bachurin. Effect of nooglutyl on the behavior and memory of SAMP10 mice with genetically determined accelerated aging. Eksp Klin Farmakol, Jul 2007; 70(4): 3-6. [in Russian].
IA Kheifets, YL Dugina, TA Voronina, GM Molodavkin, AV Martyushev-Poklad, SA Sergeeva, and OI Epstein. Involvement of the serotoninergic system in the mechanism of action of ultralow dose antibodies to S-100 protein. Bull Exp Biol Med, May 2007; 143(5): 598-600.[in Russian].
GM Molodavkin, TA Voronina, LI Larentsova, MI Pchelkina, and OK Meletova. Combined action of mexidol and non-narcotic analgesics on pain thresholds and emotional stress behavior in animals. Eksp Klin Farmakol, Mar 2007; 70(2): 16-9.[in Russian].
BB Moroz, IuB Deshevoi, TA Voronina, AV Lyrshchikova, and VG Lebedev. Effect of mexidol on hemopoietic system in conditions of an emotional stress after exposure to ionizing radiation. Radiats Biol Radioecol, Mar 2007; 47(2): 163-70. [in Russian].
AP Belnik, RU Ostrovskaya, and II Poletaeva. Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice. Bull Exp Biol Med, Apr 2007; 143(4): 431-3.[in Russian].
TA Voroninaand SB Seredenin. Nootropes (cognition enhancers) and neuroprotectors. Eksp Klin Farmakol, Jul 2007; 70(4): 44-58.[in Russian].
